Aeras and Crucell commence Phase II study of TB vaccine candidate in infants

February 15, 2016

"I am extremely pleased at the pace in which our work to develop a next generation vaccine against TB is progressing. Our successful collaboration with Aeras, enabling the initiation of yet another Phase II study, is an important step towards our ambition of reducing the global burden of this fatal disease," said Jaap Goudsmit, Crucell's Chief Scientific Officer.

Kenya is ranked 13th on a list of 22 high-burden TB countries, according to the World Health Organization. In 2007, 24,000 Kenyans died from TB and there were 132,000 new cases.

"The communities in which we work are hard hit by both TB and HIV/AIDS, two leading causes of mortality," said Videlis Nduba, MD, MPH, Principal Investigator for the trial at KEMRI/CDC Research and Public Health Collaboration. "We are pleased to apply our research expertise at this stage in the development of this vaccine-a vaccine which has undergone considerable early-stage safety testing."

AERAS-402/Crucell Ad35 has been tested in seven early-stage clinical trials including a phase I clinical trial in infants in South Africa. A Phase II trial to test its safety and efficacy in adults living with HIV is ongoing in South Africa. To date, the candidate has been shown to have an acceptable safety profile in these populations.

Source: Aeras Global TB Vaccine Foundation